LOPA is typically used when a more detailed qualitative risk assessment like HAZOP is insufficient, and the risk level is unclear or seems unacceptable from these types of risk assessments. LOPA is useful for focusing on specific high-risk scenarios or hazards where there is uncertainty about the effectiveness of existing layers of protection. LOPA is often used to establish the Safety Integrity Level (SIL) of a Safety Instrumented System (SIS), as required by standards like IEC 61511 & 61508. By quantifying the required risk reduction, LOPA determines the SIL rating, which defines the reliability and robustness required for the SIS to achieve acceptable risk levels.